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A case-cohort design for epidemiologic cohort studies and disease prevention trials

Biometrika · 1986 · Vol. 73(1) · pp. 1–11

Ross L. Prentice✉(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa)

Abstract

Suppose that a cohort of individuals is to be followed in order to relate failure rates to preceding covariate histories. A design is proposed which involves covariate data only for cases experiencing failure and for members of a randomly selected ubcohort. Odds ratio and relative risk estimation procedures are presented for such a ‘case-cohort’ design. A small simulation study compares ease-cohort relative risk estimation procedures to full-cohort and synthetic case-control analyses. Relevance to epidemiologic cohort studies and disease prevention trials is discussed.

Advanced Causal Inference Techniques Food Security and Health in Diverse Populations Statistical Methods and Bayesian InferenceCovariateCohortMedicineOdds ratioCohort studyEpidemiologyStatisticsRelative riskDemographyConfidence interval