article Open AccessTop 1% cited
Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy
BMC Cancer · 2010 · Vol. 10(1) · pp. 94–94
Oleg Nadiarnykh✉(UConn Health)Ronald LaComb(UConn Health)Molly Brewer(UConn Health)Paul J. Campagnola(UConn Health)
Abstract
Due to the large structural changes in tissue assembly and the SHG sensitivity to these collagen alterations, quantitative discrimination is achieved using small patient data sets. Ultimately these measurements may be developed as intrinsic biomarkers for use in clinical applications.
Advanced Fluorescence Microscopy TechniquesPhotoacoustic and Ultrasonic ImagingUltrasound Imaging and ElastographyExtracellular matrixCollagen fibrilSecond-harmonic generationOvarian cancerCollagen fiberMaterials scienceMatrix (chemical analysis)Biomedical engineeringBiophysicsPathology
MeSH terms
BiopsyComputer SimulationDiagnostic ImagingExtracellular MatrixFemaleHumansImage EnhancementMicroscopyMicroscopy, FluorescenceMonte Carlo MethodOvarian NeoplasmsOvaryAnisotropy
Funding
- University of Connecticut
- National Institutes of Health
Citations
272
FWCI
21.13
field-weighted impact
References
43
Percentile
99%
vs. same field & year
Citations per year
Cited by
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American Journal Of Pathology · 2011 · 1,276 citations
References
Interpreting Second-Harmonic Generation Images of Collagen I Fibrils
Biophysical Journal · 2004 · 825 citations
The principles of nonlinear optics
IEEE Journal of Quantum Electronics · 1985 · 1,185 citations
Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues
Biophysical Journal · 2002 · 906 citations
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Proceedings of the National Academy of Sciences · 2001 · 10,888 citations
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Interpreting Second-Harmonic Generation Images of Collagen I Fibrils
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