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Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Molecular Cell · 2010 · Vol. 38(5) · pp. 662–674

Kyoko L. Yap(Icahn School of Medicine at Mount Sinai)SiDe Li(Icahn School of Medicine at Mount Sinai)Ana M. Muñoz-Cabello(Imperial College London)Selina Raguz(Imperial College London)Lei Zeng(Icahn School of Medicine at Mount Sinai)Shiraz Mujtaba(Icahn School of Medicine at Mount Sinai)Jesús Gil(Imperial College London)Martin J. Walsh✉(Icahn School of Medicine at Mount Sinai)Ming‐Ming Zhou✉(Icahn School of Medicine at Mount Sinai)

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Epigenetics and DNA Methylation Cancer-related molecular mechanisms research Cancer-related gene regulationBiologyPolycomb-group proteinsChromodomainHistone H3Long non-coding RNANon-coding RNAGene silencingRNAEpigeneticsPRC2

MeSH terms

AnimalsMultigene FamilyHistonesHumansLysineMaleMethylationModels, MolecularMolecular Sequence DataProstatic NeoplasmsRepressor ProteinsTranscription, GeneticCellular SenescenceProtein Structure, TertiaryNuclear Magnetic Resonance, Biomolecular

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Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a