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BOTULINUM-A TOXIN FOR TREATING DETRUSOR HYPERREFLEXIA IN SPINAL CORD INJURED PATIENTS: A NEW ALTERNATIVE TO ANTICHOLINERGIC DRUGS? PRELIMINARY RESULTS
The Journal of Urology · 2000 · Vol. 164(3 Part 1) · pp. 692–697
Abstract
Botulinum-A toxin injections into the detrusor seem to be a safe and valuable therapeutic option in spinal cord injured patients with incontinence resistant to anticholinergic medication who perform clean intermittent self-catheterization. Successfully treated patients become continent again and may withdraw from or markedly decrease anticholinergic drug intake. A dose of 300 units botulinum-A toxin seems to be needed to counteract an overactive detrusor. The duration of bladder paresis induced by the toxin is at least 9 months, when repeat injections are required.
Botulinum Toxin and Related Neurological DisordersUrinary Bladder and Prostate ResearchAnesthesia and Pain ManagementMedicineAnticholinergicSpinal cord injuryAnticholinergic agentsHyperreflexiaDetrusor muscleUrinary incontinenceBotulinum toxinAnesthesiaOxybutynin
MeSH terms
AdolescentAdultUrinary BladderUrinary Bladder, NeurogenicCystoscopyFemaleFollow-Up StudiesHumansInjections, IntramuscularMaleMiddle AgedNeuromuscular AgentsPressureProspective StudiesSpinal Cord Injuries
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