article
Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis
Journal of Natural Products · 1992 · Vol. 55(12) · pp. 1732–1740
Abstract
The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.
Toxin Mechanisms and ImmunotoxinsTransgenic Plants and ApplicationsInsect and Pesticide ResearchFlavonesFlavonolsHerpes simplex virusCitationInformation retrievalComputer sciencePropolisSimplexWorld Wide WebTraditional medicine
MeSH terms
AnimalsAntiviral AgentsCell SurvivalDrug SynergismFlavonoidsViral Plaque AssayPropolisVero CellsVirus ReplicationSimplexvirusFlavonols
Citations
297
FWCI
0.55
field-weighted impact
References
0
Percentile
63%
vs. same field & year
Citations per year
Cited by
Recent Advances in the Chemical Composition of Propolis
Molecules · 2014 · 736 citations
Plant Products as Antimicrobial Agents
Clinical Microbiology Reviews · 1999 · 8,847 citations
Propolis and the immune system: a review
Journal of Ethnopharmacology · 2007 · 708 citations
Seasonal effect on Brazilian propolis antibacterial activity
Journal of Ethnopharmacology · 2000 · 503 citations
Flavones: An important scaffold for medicinal chemistry
European Journal of Medicinal Chemistry · 2014 · 520 citations
Functional Properties of Honey, Propolis, and Royal Jelly
Journal of Food Science · 2008 · 861 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.