article Open AccessTop 10% cited

GDC-0449—A potent inhibitor of the hedgehog pathway

Bioorganic & Medicinal Chemistry Letters · 2009 · Vol. 19(19) · pp. 5576–5581

Kirk Robarge✉Shirley A. Brunton(Evotec (United Kingdom))Georgette M. CastanedoYong CuiMichael S. DinaRichard GoldsmithStephen E. Gould(Curis (United States))Oivin Guichert(Curis (United States))Janet L. GunznerJason HalladayWei JiaCyrus KhojastehMichael F. T. KoehlerKaren Kotkow(Curis (United States))Hank LaRebecca Lyn LaLondeKevin LauLeslie LeeDerek MarshallJames C. MarstersLesley MurrayChanggeng Qian(Curis (United States))Lee L. Rubin(Curis (United States))Laurent SalphatiMark StanleyJ. H. A. STIBBARD(Evotec (United Kingdom))Daniel P. SutherlinSavita UbhayakerShumei WangSusan WongMinli Xie

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Hedgehog Signaling Pathway Studies Genetic and rare skin diseases.Ocular Disorders and TreatmentsChemistryBenzimidazoleAmideVismodegibHedgehog signaling pathwayStereochemistryHedgehogPharmacologyPotencyChemical synthesis

MeSH terms

AmidesAnilidesAnimalsBenzimidazolesCarcinoma, Basal CellBasal Cell CarcinomaCell LineCerebellar NeoplasmsHumansMedulloblastomaMice, NudePyridinesStructure-Activity RelationshipSignal TransductionXenograft Model Antitumor Assays

Citations

385

FWCI

10.76

field-weighted impact

References

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99%

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Cited by

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References

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Genes & Development · 2002 · 1,464 citations

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