articleTop 10% cited
A Longitudinal Study of Brain Volume Changes in Normal Aging Using Serial Registered Magnetic Resonance Imaging
Archives of Neurology · 2003 · Vol. 60(7) · pp. 989–989
Rachael I. Scahill✉(UK Dementia Research Institute)Chris Frost(London School of Hygiene & Tropical Medicine)Rhian Jenkins(UCL Australia)Jennifer L. Whitwell(UK Dementia Research Institute)Martin N. Rossor(Imperial College London)Nick C. Fox(UCL Australia)
Abstract
We found a significant age-associated decrease in global and regional brain volumes. Some evidence indicates that this decline in brain volumes may be due to a nonlinear acceleration in rates of atrophy with increasing age. A better understanding of this process may help to discriminate normal age-related changes from neurodegenerative diseases.
Functional Brain Connectivity StudiesDementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAtrophyMagnetic resonance imagingBrain sizeTemporal lobeCardiologyMedicineLateral ventriclesBrain agingLongitudinal studyInternal medicine
MeSH terms
AdultAgedAgingAtrophyBrainCross-Sectional StudiesFemaleHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedRadiographySex Factors
Funding
- Alzheimer's Society
- Alzheimer's Research Trust
- Medical Research Council
Citations
933
FWCI
9.28
field-weighted impact
References
41
Percentile
99%
vs. same field & year
Citations per year
Cited by
Consistent neuroanatomical age-related volume differences across multiple samples
Neurobiology of Aging · 2009 · 525 citations
Beneficial effects of physical exercise on neuroplasticity and cognition
Neuroscience & Biobehavioral Reviews · 2013 · 976 citations
When does age-related cognitive decline begin?
Neurobiology of Aging · 2009 · 1,814 citations
Differential aging of the brain: Patterns, cognitive correlates and modifiers
Neuroscience & Biobehavioral Reviews · 2006 · 1,186 citations
Efficiency and Cost of Economical Brain Functional Networks
PLoS Computational Biology · 2007 · 2,567 citations
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Cerebral Cortex · 2005 · 2,902 citations
References
Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights
Annals of Neurology · 1978 · 1,010 citations
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Neurology · 1997 · 1,125 citations
Statistical parametric maps in functional imaging: A general linear approach
Human Brain Mapping · 1994 · 9,759 citations
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
NeuroImage · 2001 · 4,577 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.