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Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo

Developmental Biology · 2002 · Vol. 241(1) · pp. 172–182

Fátima Santos(Babraham Institute)Brian Hendrich(Wellcome Centre for Cell Biology)Wolf Reik(Babraham Institute)Wendy Dean✉(Babraham Institute)

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Epigenetics and DNA Methylation Genetic Syndromes and Imprinting Prenatal Screening and DiagnosticsReprogrammingBiologyPronucleusDNA demethylationDNA methylationEpigeneticsGenomic imprintingMethylationZygoteBlastocyst

MeSH terms

AnimalsBlastocystChromatinCleavage Stage, OvumDNA-Binding ProteinsFemaleFertilizationEmbryonic and Fetal DevelopmentMaleMice, Inbred CBAMice, Inbred C57BLOocytesZygoteMice, KnockoutGenomic Imprinting

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Active demethylation of the paternal genome in the mouse zygote

Current Biology · 2000 · 959 citations

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Cytosine methylation and the ecology of intragenomic parasites

Trends in Genetics · 1997 · 1,928 citations

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Cell · 1999 · 6,039 citations

Genomic imprinting: parental influence on the genome

Nature Reviews Genetics · 2001 · 2,276 citations

Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

Molecular and Cellular Biology · 1998 · 1,344 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

Development · 1987 · 1,089 citations

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