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Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
Arthritis & Rheumatism · 1993 · Vol. 36(12) · pp. 1681–1690
Michael J. Elliott✉(Kennedy Center)Ravinder N. MainiMarc FeldmannA. Long-FoxP. CharlesPeter D. Katsikis(Charing Cross Hospital)Fionula M. Brennan(Charing Cross Hospital)Jean WalkerHanny Bijl(Charing Cross Hospital)John Ghrayeb(Charing Cross Hospital)James N. Woody(Charing Cross Hospital)
Abstract
Treatment with anti-TNF alpha was safe and well tolerated and resulted in significant clinical and laboratory improvements. These preliminary results support the hypothesis that TNF alpha is an important regulator in RA, and suggest that it may be a useful new therapeutic target in this disease.
Rheumatoid Arthritis Research and TherapiesMonoclonal and Polyclonal Antibodies ResearchAutoimmune and Inflammatory Disorders ResearchMedicineRheumatoid arthritisTumor necrosis factor alphaInternal medicineMonoclonal antibodyGastroenterologyLiterMonoclonalAdverse effectArthritis
MeSH terms
AdultAgedAntibodies, MonoclonalArthritis, RheumatoidChimeraDose-Response Relationship, ImmunologicFemaleHumansImmunotherapyMaleMiddle AgedTumor Necrosis Factor-alphaCytokines
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References
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The EMBO Journal · 1991 · 1,647 citations
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
Journal of Immunological Methods · 1986 · 1,257 citations
Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis
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