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Characterized Chondrocyte Implantation Results in Better Structural Repair when Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus Microfracture

The American Journal of Sports Medicine · 2008 · Vol. 36(2) · pp. 235–246

Daniël B.F. Saris✉(Utrecht University)Johan Vanlauwe(KU Leuven)Jan Victor(AZ Sint-Lucas)Miroslav Hašpl(University of Zagreb)Michael Bohnsack(Medizinische Hochschule Hannover)Yves Fortems(AZ Sint-Lucas)Bruno Vandekerckhove(AZ Sint-Jan)Karl Almqvist(Ghent University Hospital)Toon ClaesFrank Handelberg(Universitair Ziekenhuis Brussel)Koen Lagae(Service Public Federal Finances)Jan Van Der Bauwhede(AZ Groeninge)Hilde Vandenneucker(KU Leuven)K.G. Auw Yang(Utrecht University)Mislav Jelić(University of Zagreb)René Verdonk(Ghent University Hospital)Nancy VeulemansJohan Bellemans(KU Leuven)Frank P. Luyten(KU Leuven)

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Abstract

One year after treatment, characterized chondrocyte implantation was associated with a tissue regenerate that was superior to that after microfracture. Short-term clinical outcome was similar for both treatments. The superior structural outcome may result in improved long-term clinical benefit with characterized chondrocyte implantation. Long-term follow-up is needed to confirm these findings.

Osteoarthritis Treatment and Mechanisms Knee injuries and reconstruction techniques Total Knee Arthroplasty OutcomesMedicineChondrocyteCartilageOsteoarthritisAutologous chondrocyte implantationSurgeryRandomized controlled trialArticular cartilagePathologyAnatomy

MeSH terms

AdultBiopsy, NeedleCartilage, ArticularFemaleHumansKnee InjuriesMaleProspective StudiesRegenerationTreatment OutcomeChondrocytesArthroplasty, Subchondral