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Reversal of late septic shock with supraphysiologic doses of hydrocortisone
Critical Care Medicine · 1998 · Vol. 26(4) · pp. 645–650
Pierre‐Édouard Bollaert✉(Centre Hospitalier Régional et Universitaire de Nancy)Claire Charpentier(Centre Hospitalier Régional et Universitaire de Nancy)Bruno Lévy(Centre Hospitalier Régional et Universitaire de Nancy)Marc Debouverie(Centre Hospitalier Régional et Universitaire de Nancy)Gérard Audibert(Centre Hospitalier Régional et Universitaire de Nancy)A Larcan(Centre Hospitalier Régional et Universitaire de Nancy)
Abstract
Administration of modest doses of hydrocortisone in the setting of pressor-dependent septic shock for a mean of >96 hrs resulted in a significant improvement in hemodynamics and a beneficial effect on survival. These beneficial effects do not appear related to adrenocortical insufficiency.
Adrenal Hormones and DisordersSepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyMedicineSeptic shockHydrocortisoneShock (circulatory)Internal medicineSepsis
MeSH terms
AdultAgedAged, 80 and overAnti-Inflammatory AgentsCatecholaminesDouble-Blind MethodFemaleHemodynamicsHumansHydrocortisoneMaleMiddle AgedShock, SepticAPACHE
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References
Prognosis in Acute Organ-System Failure
Annals of Surgery · 1985 · 1,238 citations
A simplified acute physiology score for ICU patients
Critical Care Medicine · 1984 · 1,262 citations
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