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Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre‐eclamptic pregnancies

BJOG An International Journal of Obstetrics & Gynaecology · 1998 · Vol. 105(6) · pp. 632–640
Marian KnightChristopher RedmanElizabeth A. LintonIan L. Sargent

Abstract

STBM are shed into the maternal circulation (microvillous deportation) and are present in significantly increased amounts in pre-eclamptic women. They may contribute to the endothelial dysfunction underlying the maternal syndrome of pre-eclampsia.

Pregnancy and preeclampsia studiesMaternal and fetal healthcareReproductive System and PregnancySyncytiotrophoblastMedicineEclampsiaPlacentaPreeclampsiaInternal medicinePlacental CirculationEndocrinologyEndothelial dysfunctionPregnancy

MeSH terms

AdultEndothelium, VascularFemaleFlow CytometryHumansMicrovilliPre-EclampsiaPregnancyTrophoblastsVascular DiseasesFluoroimmunoassay
Citations
495
FWCI
15.59
field-weighted impact
References
26
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References
Preeclampsia: An endothelial cell disorder
American Journal of Obstetrics and Gynecology · 1989 · 1,863 citations
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