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Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

BMC Genomics · 2010 · Vol. 11(1) · pp. 643–643

Jared V. Goldstone✉(Woods Hole Oceanographic Institution)Andrew G. McArthurAkira Kubota(Woods Hole Oceanographic Institution)Juliano Zanette(Universidade Federal do Rio Grande)Thiago Estevam Parente(Woods Hole Oceanographic Institution)Maria Jönsson(Uppsala University)David R. Nelson(University of Tennessee Health Science Center)John J. Stegeman(Woods Hole Oceanographic Institution)

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Abstract

Transcript profiling by microarray and quantitative PCR revealed that the majority of zebrafish CYP genes are expressed in embryos, with waves of expression of different sets of genes over the course of development. Transcripts of some CYP occur also in oocytes. The results provide a foundation for the use of zebrafish as a model in toxicological, pharmacological and chemical disease research.

Pharmacogenetics and Drug Metabolism Epigenetics and DNA Methylation Zebrafish Biomedical Research ApplicationsBiologyZebrafishCytochrome P450GeneGeneticsGene expressionEnzymeBiochemistry

MeSH terms

Amino Acid SequenceAnimalsCytochrome P-450 Enzyme SystemFertilizationHumansOocytesPhylogenyTime FactorsZebrafishGene Expression Regulation, EnzymologicLikelihood FunctionsGene Expression Regulation, DevelopmentalReverse Transcriptase Polymerase Chain ReactionSyntenyFish Proteins