The Modified Wilson Model and Predicting Drug Solubility in Water-Cosolvent Mixtures.

Abstract

Applicability of the modified Wilson model for calculating drug solubility in water-cosolvent mixtures is presented. The accuracy and predictability of the model are compared with those of other models which calculate solute solubility as a function of the solvent composition. Mean of percent deviations from experimental values are 7.77, 8.70, 9.06, 10.72, 10.72 and 18.71, for the modified Wilson, double-log exponential, general single model, combined nearly ideal binary solvent/Redlich-Kister, excess free energy and mixture response surface methods, respectively.