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Mechanisms of action, physiological effects, and complications of hypothermia
Critical Care Medicine · 2009 · Vol. 37(Supplement) · pp. S186–S202
Kees H. Polderman✉(University of Pittsburgh)
Abstract
Therapeutic hypothermia is a highly promising treatment, but the potential side effects need to be properly managed particularly if prolonged treatment periods are required. Understanding the underlying mechanisms, awareness of physiological changes associated with cooling, and prevention of potential side effects are all key factors for its effective clinical usage.
Cardiac Arrest and ResuscitationThermal Regulation in MedicineRespiratory Support and MechanismsMedicineHypothermiaHypovolemiaBradycardiaAnesthesiaIschemiaBlood pressureInternal medicineHeart rate
MeSH terms
AcidosisBody Temperature RegulationBrain EdemaCalpainBrain IschemiaCritical CareEpilepsyFree RadicalsHumansHypothermia, InducedInfectionsInflammationMitochondriaThrombosisThromboxane A2
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