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Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Bioorganic & Medicinal Chemistry Letters · 2010 · Vol. 20(10) · pp. 3142–3145

Jerome C. Bressi(Takeda (United States))Andy Jennings(Takeda (United States))R.J. Skene(Takeda (United States))Yiqin Wu(Takeda (United States))Robert Melkus(Takeda (United States))Ron de Jong(Takeda (United States))Shawn M. O’Connell(Takeda (United States))Charles E. Grimshaw(Takeda (United States))Marc Navre(Takeda (United States))Anthony R. Gangloff✉(Takeda (United States))

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Histone Deacetylase Inhibitors Research Peptidase Inhibition and Analysis Protein Degradation and InhibitorsChemistryBenzamideCytotoxicityStereochemistryCrystal structureCarboxamideStructure–activity relationshipIn vitroBiochemistryOrganic chemistry

MeSH terms

BenzamidesBinding SitesHumansKineticsStructure-Activity RelationshipCrystallography, X-RayCatalytic DomainHCT116 CellsHistone Deacetylase 2Histone Deacetylase Inhibitors

Citations

251

FWCI

10.41

field-weighted impact

References

Percentile

99%

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Citations per year

References

The language of covalent histone modifications

Nature · 2000 · 8,530 citations

General atomic and molecular electronic structure system

Journal of Computational Chemistry · 1993 · 20,111 citations

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