articleTop 1% cited
A MICROASSAY FOR CELL-MEDIATED IMMUNITY
Transplantation · 1970 · Vol. 9(3) · pp. 219–227
Mitsuo Takasugi✉(National Postdoctoral Association)Eva Klein(Karolinska Institutet)
Abstract
SUMMARY A method for assaying cell-mediated cytotoxicity against cultured target cells in 10 µl of medium is described. The test possesses sufficient sensitivity to detect tumor-specific as well as histocompatibility antigens. Lymphoid cells from the peritoneal cavity, spleen, and peripheral blood exhibited strong cytotoxicity, while lymph node cells were less effective. Reduction of target cell survival was also observed with cells from mice receiving either single or multiple immunizations.
Immunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies ResearchRNA Interference and Gene DeliveryCytotoxicitySpleenLymph nodeHistocompatibilityImmunologyAntigenCellImmunityPeritoneal cavityBiology
MeSH terms
AnimalsAntigen-Antibody ReactionsBone MarrowBone Marrow CellsFibroblastsImmunoassayLymph NodesLymphocytesMethodsNeoplasms, ExperimentalPeritoneumSpleenThymus GlandCulture TechniquesMice
Citations
481
FWCI
25.47
field-weighted impact
References
0
Percentile
100%
vs. same field & year
Cited by
Demonstration of cell‐mediated immunity to human neoplasms of various histological types
International Journal of Cancer · 1971 · 666 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.