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GENOTYPIC VARIATION IN THE TRANSFORMING GROWTH FACTOR-??1 GENE

Transplantation · 1998 · Vol. 66(8) · pp. 1014–1020

Mohammed R. Awad✉(University of Manchester)Ahmed El‐GamelP S HasletonDavid M. Turner(St Mary's Hospital)Paul J. Sinnott(St Mary's Hospital)Ian V. Hutchinson(University of Manchester)

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Abstract

The production of TGF-beta1 is under genetic control, and this in turn influences the development of lung fibrosis. Hence, the TGF-beta1 genotype has prognostic significance in transplant recipients.

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Transplantation: Methods and Outcomes Tracheal and airway disordersGenotypeBiologyArginineAlleleTransforming growth factorLung transplantationMolecular biologyTransplantationFibrosisAllele frequency

MeSH terms

AllelesGenotypeHumansPolymorphism, GeneticPostoperative ComplicationsPulmonary FibrosisGenetic VariationLung TransplantationTransforming Growth Factor beta

Citations

641

FWCI

23.96

field-weighted impact

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100%

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References

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.