reviewTop 1% cited
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Atherosclerosis · 2000 · Vol. 148(2) · pp. 209–214
John S Yudkin✉(Whittington Hospital)Meena Kumari(University College London)Steve E. Humphries(University College London)Vidya Mohamed‐Ali(Whittington Hospital)
Adipokines, Inflammation, and Metabolic DiseasesBlood properties and coagulationAtherosclerosis and Cardiovascular DiseasesInflammationFibrinogenMedicineProinflammatory cytokineSerum amyloid AAcute-phase proteinInternal medicineCytokineTumor necrosis factor alphaEndocrinology
MeSH terms
AnimalsArteriosclerosisCoronary DiseaseHumansObesityRisk FactorsStress, PhysiologicalThrombosisVasculitisInterleukin-6
Funding
- Sir Jules Thorn Charitable Trust
- Medical Research Council
Citations
1,765
FWCI
59.72
field-weighted impact
References
54
Percentile
100%
vs. same field & year
Citations per year
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References
Interleukin-6 and the acute phase response
Biochemical Journal · 1990 · 2,757 citations
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Journal of Clinical Investigation · 1995 · 3,504 citations
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Diabetes · 1994 · 1,292 citations
Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly
The American Journal of Medicine · 1999 · 1,479 citations
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid<sup>1</sup>
The Journal of Clinical Endocrinology & Metabolism · 1998 · 1,529 citations
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.
Journal of Clinical Investigation · 1998 · 2,239 citations
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.
Journal of Clinical Investigation · 1994 · 2,527 citations
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction
Arteriosclerosis Thrombosis and Vascular Biology · 1999 · 2,458 citations
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