reviewTop 1% cited
The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM
Diabetes · 1988 · Vol. 37(6) · pp. 667–687
Ralph A. DeFronzo✉(Yale University)
Abstract
Apres l'ingestion de glucose, l'insulino-secretion du pancreas est stimulee et la combinaison de l'hyperglycemie et de l'hyperinsulinemie doit induire la captation de glucose dans les territoires splanchique (foie et tube digestif) et peripherique (muscles) et la suppression de la production hepatique du glucose. Le but de cette conference est de prouver que, bien que la perturbation du metabolisme hepatique du glucose joue un role dans le maintien de l'etat diabetique, le foie ne joue probablement pas de role majeur dans le developpement precoce de l'hyperglycemie a jeun des DNID
Liver Disease Diagnosis and TreatmentDiabetes and associated disordersPancreatic function and diabetesCollusionInternal medicineEndocrinologyBiologyMedicineBusiness
MeSH terms
Insulin SecretionDiabetes Mellitus, Type 2GlucoseHumansHyperglycemiaInsulinInsulin ResistanceIslets of LangerhansLiverMusclesOxidation-ReductionLipid Metabolism
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