article Open AccessTop 1% cited
Translocation of Inhaled Ultrafine Manganese Oxide Particles to the CentralNervous System
Environmental Health Perspectives · 2006 · Vol. 114(8) · pp. 1172–1178
Alison Elder✉(University of Rochester)Robert Gelein(University of Rochester)Vanessa Silva(University of Rochester)Tessa Feikert(University of Rochester)Lisa A. Opanashuk(University of Rochester)Janet Carter(Procter & Gamble (United States))Russell M. Potter(Owens Corning (United States))Andrew Maynard(Woodrow Wilson International Center for Scholars)Yasuo Ito(Northern Illinois University)Jacob N. Finkelstein(University of Rochester)Günter Oberdörster(University of Rochester)
Abstract
We conclude that the olfactory neuronal pathway is efficient for translocating inhaled Mn oxide as solid UFPs to the central nervous system and that this can result in inflammatory changes. We suggest that despite differences between human and rodent olfactory systems, this pathway is relevant in humans.
Heavy Metal Exposure and ToxicityMercury impact and mitigation studiesElectrochemical Analysis and ApplicationsOlfactory bulbNostrilUltrafine particleOlfactory epitheliumChemistryGlial fibrillary acidic proteinOlfactory systemCentral nervous systemPathologyEndocrinology
MeSH terms
AnimalsBrainBronchoalveolar Lavage FluidCentral Nervous SystemChloridesMaleNerve Tissue ProteinsOlfactory BulbOxidation-ReductionOxidesRats, Inbred F344RNASolubilityTissue DistributionBlotting, Western
Funding
- U.S. Department of Defense
- U.S. Department of Energy
- U.S. Environmental Protection Agency
- Multidisciplinary University Research Initiative
- National Institute for Occupational Safety and Health
Citations
1,161
FWCI
37.64
field-weighted impact
References
43
Percentile
100%
vs. same field & year
Citations per year
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References
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
Biochemical Journal · 2004 · 2,791 citations
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Environmental Health Perspectives · 2005 · 7,739 citations
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