Stoffwechselprodukte von Mikroorganismen 143. Mitteilung. Echinocandin B, ein neuartiges Polypeptid‐Antibioticum aus <i>Aspergillus nidulans var. echinulatus</i>: Isolierung und Bausteine

Abstract

From a strain of Aspergillus nidulans var. echinulatus , A 32204, echinocandin, a novel polypeptide antibiotic complex with high and specific anti‐yeast activity was isolated. The main component, echinocandin B, was separated by counter‐current distribution. A tentative molecular formula C 52 H 81 N 7 O 18 is discussed. The antibiotic is characterized by its IR. and NMR. spectra and by its characteristic hydrolytic degradation products: linoilic acid, L ‐4‐hydroxyproline, L ‐4‐oxoproline, (2 S , 3 S , 4 S )‐4‐methyl‐3‐hydroxy‐proline, L ‐threonine (2 mols), and 1‐( p ‐hydroxyphenyl)‐3‐amino‐propan‐2‐one.