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Epigenetic remodeling of the fungal secondary metabolome

Organic & Biomolecular Chemistry · 2008 · Vol. 6(11) · pp. 1895–1895

Russell B. Williams(University of Oklahoma)Jon C. Henrikson(University of Oklahoma)Ashley R. Hoover(University of Oklahoma)Andrlynn E. Lee(University of Oklahoma)Robert H. Cichewicz✉(University of Oklahoma)

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Abstract

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

Microbial Natural Products and Biosynthesis Fungal Biology and Applications Plant-Microbe Interactions and ImmunityMetabolomeChemistryEpigeneticsMethyltransferaseHistone deacetylaseHistoneNatural productSmall moleculeBiomoleculeHistone acetyltransferase

MeSH terms

Chromatography, High Pressure LiquidChromatography, Thin LayerFungiMagnetic Resonance SpectroscopyRNA, RibosomalSpectrophotometry, UltravioletMass SpectrometryEpigenesis, Genetic

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Triggering cryptic natural product biosynthesis in microorganisms

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