reviewTop 10% cited
Biology of Intervertebral Disc Aging and Degeneration
Spine · 2004 · Vol. 29(23) · pp. 2691–2699
Peter J. Roughley✉(Shriners Hospitals for Children - Canada)
Abstract
Changes in intervertebral disc structure throughout life ultimately result in tissue degeneration and the need for medical intervention. Current research is aimed at trying to restore the integrity of the degenerate disc matrix by biologic means, although at present it is not clear what the structure of the most appropriate repair tissue should be or how it can be achieved.
Spine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationShoulder Injury and TreatmentDegeneration (medical)Intervertebral discExtracellular matrixMedicineAggrecanIntervertebral diskAnatomyNeurosciencePathologyCell biology
MeSH terms
AgingExtracellular MatrixHumansIntervertebral DiscIntervertebral Disc Displacement
Citations
774
FWCI
9.70
field-weighted impact
References
78
Percentile
99%
vs. same field & year
Citations per year
Cited by
Intervertebral Disk Degeneration and Repair
Neurosurgery · 2017 · 468 citations
The role of IL-1β and TNF-α in intervertebral disc degeneration
Biomedicine & Pharmacotherapy · 2020 · 581 citations
What is Intervertebral Disc Degeneration, and What Causes It?
Spine · 2006 · 1,742 citations
References
Aging and Degeneration of the Human Intervertebral Disc
Spine · 1995 · 1,299 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.