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Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE

Allergy · 2004 · Vol. 60(3) · pp. 309–316
Marc HumbertRichard BeasleyJon G. AyresRaymond G. SlavinJean‐Louis HébertJean BousquetK.M. BeehSância RamosGiorgio Walter CanonicaS. HedgecockH. FoxMartin BloggK. Surrey

Abstract

In patients with inadequately controlled severe persistent asthma, despite high-dose ICS and LABA therapy, and often additional therapy, omalizumab significantly reduced the rate of clinically significant asthma exacerbations, severe exacerbations and emergency visits. Omalizumab is effective and should be considered as add-on therapy for patients with inadequately controlled severe persistent asthma who have a significant unmet need despite best available therapy.

Asthma and respiratory diseasesRespiratory and Cough-Related ResearchInhalation and Respiratory Drug DeliveryOmalizumabMedicineAsthmaExacerbationPlaceboAdverse effectPopulationInternal medicinePediatricsIncidence (geometry)

MeSH terms

OmalizumabAdministration, InhalationAdolescentAdrenal Cortex HormonesAdrenergic beta-AgonistsAdultAgedAntibodies, Anti-IdiotypicAntibodies, MonoclonalAsthmaDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleForced Expiratory Volume
Citations
1,110
FWCI
21.08
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
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