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Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
Allergy · 2004 · Vol. 60(3) · pp. 309–316
Marc Humbert✉(Hôpital Antoine-Béclère)Richard Beasley(Medical Research Institute of New Zealand)Jon G. AyresRaymond G. Slavin(Saint Louis University)Jean‐Louis Hébert(Centre for Research in Astrophysics of Québec)Jean Bousquet(Hôpital Arnaud de Villeneuve)K.M. Beeh(Johannes Gutenberg University Mainz)Sância Ramos(Hospital Universitario Central de Asturias)Giorgio Walter Canonica(Ospedale Policlinico San Martino)S. Hedgecock(Novartis (United Kingdom))H. Fox(Novartis (United Kingdom))Martin Blogg(Novartis (United Kingdom))K. Surrey(Novartis (United Kingdom))
Abstract
In patients with inadequately controlled severe persistent asthma, despite high-dose ICS and LABA therapy, and often additional therapy, omalizumab significantly reduced the rate of clinically significant asthma exacerbations, severe exacerbations and emergency visits. Omalizumab is effective and should be considered as add-on therapy for patients with inadequately controlled severe persistent asthma who have a significant unmet need despite best available therapy.
Asthma and respiratory diseasesRespiratory and Cough-Related ResearchInhalation and Respiratory Drug DeliveryOmalizumabMedicineAsthmaExacerbationPlaceboAdverse effectPopulationInternal medicinePediatricsIncidence (geometry)
MeSH terms
OmalizumabAdministration, InhalationAdolescentAdrenal Cortex HormonesAdrenergic beta-AgonistsAdultAgedAntibodies, Anti-IdiotypicAntibodies, MonoclonalAsthmaDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleForced Expiratory Volume
Citations
1,110
FWCI
21.08
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
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References
The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
European Respiratory Journal · 2001 · 826 citations
Efficacy and tolerability of anti‐immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLAR
Allergy · 2004 · 404 citations
Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.
Thorax · 1992 · 1,235 citations
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
Journal of Allergy and Clinical Immunology · 2001 · 1,287 citations
The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
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