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SDZ RAD, A NEW RAPAMYCIN DERIVATIVE
Transplantation · 1997 · Vol. 64(1) · pp. 36–42
W. Schüler✉(Novartis (Switzerland))Richard Sedrani(Novartis (Switzerland))Sylvain Cottens(Novartis (Switzerland))Barbara H berlin(Novartis (Switzerland))Manfred Schulz(Novartis (Switzerland))Henk‐Jan Schuurman(Novartis (Switzerland))Gerhard Zenke(Novartis (Switzerland))Hans‐Günter Zerwes(Novartis (Switzerland))Max H. Schreier(Novartis (Switzerland))
Abstract
In conclusion, SDZ RAD is a new, orally active rapamycin-derivative that is immunosuppressive and that efficiently prevents graft rejection in rat models of allotransplantation. SDZ RAD has therefore been selected for development for use in combination with cyclosporine A to prevent acute and chronic rejection after solid organ allotransplantation.
Bioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsBeetle Biology and Toxicology StudiesDerivative (finance)ChemistryBusiness
MeSH terms
AbdomenEverolimusAdministration, OralAnimalsCarrier ProteinsCell DivisionDNA-Binding ProteinsDose-Response Relationship, DrugGlomerulonephritisGraft RejectionGraft vs Host ReactionGrowth InhibitorsGrowth SubstancesHeat-Shock ProteinsHumans
Citations
536
FWCI
16.48
field-weighted impact
References
35
Percentile
100%
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References
THE IMPACT OF AN ACUTE REJECTION EPISODE ON LONG-TERM RENAL ALLOGRAFT SURVIVAL (t1/2)1,2
Transplantation · 1994 · 446 citations
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