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Global Burden of Sickle Cell Anaemia in Children under Five, 2010–2050: Modelling Based on Demographics, Excess Mortality, and Interventions

PLoS Medicine · 2013 · Vol. 10(7) · pp. e1001484–e1001484

Frédéric B. Piel✉(University of Oxford)Simon I Hay(University of Oxford)Sunetra Gupta(University of Oxford)D. J. Weatherall(MRC Weatherall Institute of Molecular Medicine)Thomas N. Williams(St Mary's Hospital)

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Abstract

Our quantitative approach confirms that the global burden of SCA is increasing, and highlights the need to develop specific national policies for appropriate public health planning, particularly in low- and middle-income countries. Further empirical collaborative epidemiological studies are vital to assess current and future health care needs, especially in Nigeria, the Democratic Republic of the Congo, and India.

Hemoglobinopathies and Related Disorders Iron Metabolism and Disorders Global Maternal and Child HealthMedicinePsychological interventionConfidence intervalGlobal healthDisease burdenPopulationDemographyEnvironmental healthPediatricsPublic health

MeSH terms

Bayes TheoremBirth RateChild, PreschoolDemographyHumansInfantInfant, NewbornModels, TheoreticalPopulation DensityRisk FactorsSickle Cell TraitTime FactorsGlobal HealthCost of Illness