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Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content.
Heart · 1993 · Vol. 69(5) · pp. 377–381
Michael J. Davies✉(British Heart Foundation)P. D. Richardson(St George's, University of London)N. J. Woolf(British Heart Foundation)David R. Katz(St George's, University of London)Jessica M. Mann(British Heart Foundation)
Abstract
In the aorta ulceration and thrombosis were characteristic of plaques with a high proportion of their volume occupied by extracellular lipid, and in which there was a shift toward a preponderance of monocyte/macrophages compared with smooth muscle cells in the cap.
Atherosclerosis and Cardiovascular DiseasesAortic Thrombus and EmbolismLipoproteins and Cardiovascular HealthMedicineThrombosisFibrous capPathologyFoam cellMonocyteMacrophageExtracellularVascular diseaseMyocyte
MeSH terms
AgedAortaArteriosclerosisCell CountHumansImmunohistochemistryLipidsMacrophagesMaleMuscle, Smooth, VascularRisk FactorsThrombosis
Citations
1,131
FWCI
8.70
field-weighted impact
References
31
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98%
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References
Atherosclerotic plaque caps are locally weakened when macrophages density is increased
Atherosclerosis · 1991 · 544 citations
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Heart · 1985 · 1,993 citations
Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
Journal of Histochemistry & Cytochemistry · 1984 · 3,207 citations
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.
The Journal of Cell Biology · 1986 · 1,635 citations
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