article Open AccessTop 1% cited
Obesity is associated with impaired immune response to influenza vaccination in humans
International Journal of Obesity · 2011 · Vol. 36(8) · pp. 1072–1077
Patricia A. Sheridan✉(University of North Carolina at Chapel Hill)Heather A. Paich(University of North Carolina at Chapel Hill)Jean Handy(University of North Carolina at Chapel Hill)Erik A. Karlsson(University of North Carolina at Chapel Hill)Michael G. Hudgens(University of North Carolina at Chapel Hill)A B Sammon(University of North Carolina at Chapel Hill)Lou Holland(University of North Carolina at Chapel Hill)Samuel S. Weir(University of North Carolina at Chapel Hill)Terry L. Noah(University of North Carolina at Chapel Hill)Melinda A. Beck(University of North Carolina at Chapel Hill)
Abstract
These results suggest obesity may impair the ability to mount a protective immune response to influenza virus.
Influenza Virus Research StudiesImmune Cell Function and InteractionDiabetes and associated disordersMedicineImmunologyVaccinationImmune systemInfluenza vaccinePopulationInfluenza A virusCD8AntibodyBody mass index
MeSH terms
AdultAntibodies, ViralAntibody FormationCells, CulturedEnzyme-Linked Immunosorbent AssayFemaleHemagglutination Inhibition TestsHumansInfluenza VaccinesInterferon-gammaLymphocyte ActivationMaleMiddle AgedObesityInfluenza A Virus, H1N1 Subtype
Funding
- National Institutes of Health
Citations
597
FWCI
12.57
field-weighted impact
References
27
Percentile
99%
vs. same field & year
Citations per year
Cited by
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Obesity and the risk and outcome of infection
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References
Influenza vaccine: The challenge of antigenic drift
Vaccine · 2007 · 728 citations
Antibody response to influenza vaccination in the elderly: A quantitative review
Vaccine · 2005 · 1,058 citations
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