articleTop 10% cited
Improved Procedure for the Oxidative Cleavage of Olefins by OsO<sub>4</sub>−NaIO<sub>4</sub>
Organic Letters · 2004 · Vol. 6(19) · pp. 3217–3219
Wensheng Yu✉(University of Iowa)Yan Mei(University of Iowa)Ying Kang(University of Iowa)Zhengmao Hua(University of Iowa)Zhendong Jin(University of Iowa)
Abstract
[reaction: see text] Oxidative cleavage of olefins by OsO(4)-NaIO(4) sometimes suffers from low yields due to the formation of side products. It is found that the addition of 2,6-lutidine can suppress the side reactions and dramatically improve the yield of this classic reaction.
Oxidative Organic Chemistry ReactionsChemical Synthesis and ReactionsCatalytic C–H Functionalization MethodsChemistryOxidative cleavageYield (engineering)Oxidative phosphorylationCleavage (geology)Reaction conditionsMedicinal chemistryStereochemistryPhotochemistryOrganic chemistry
MeSH terms
AldehydesAlkenesCatalysisChemistry, OrganicIodatesOxidation-ReductionPyridinesMolecular StructureOsmium Compounds
Citations
428
FWCI
8.21
field-weighted impact
References
6
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98%
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References
Notes - Osmium Tetroxide-Catalyzed Periodate Oxidation of Olefinic Bonds
The Journal of Organic Chemistry · 1956 · 661 citations
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