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ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS
The Journal of General Physiology · 1943 · Vol. 26(3) · pp. 325–331
D.B. Zilversmit✉(University of California, Berkeley)C. Entenman(University of California, Berkeley)M. C. Fishler(University of California, Berkeley)
Abstract
1. A new method for the determination of an immediate precursor of a substance occurring in the animal body is presented. 2. Calculations on the quantitative determination of the rate of turnover of a substance and their application to experiments involving the use of labeling agents are given. These calculations take into account loss of the isotopic substance by way of breakdown or transport.
Chemical Reactions and IsotopesChemistryTurnoverProtein turnoverChromatographyBiophysicsBiochemistryBiology
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