articleTop 1% cited
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
Arthritis & Rheumatism · 2003 · Vol. 48(10) · pp. 2741–2749
Solbritt Rantapää‐Dahlqvist✉(Umeå University)B.A.W. de Jong(Radboud University Nijmegen)Ewa Berglin(Umeå University)Göran Hallmans(Umeå University)Göran Wadell(Umeå University)Hans Stenlund(Umeå University)Ulf Sundin(Stockholm University College of Music Education)Walther J. van Venrooij(Radboud University Nijmegen)
Abstract
Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years. The presence of anti-CCP and IgA-RF predicted the development of RA, with anti-CCP antibody having the highest predictive value. This indicates that citrullination and the production of anti-CCP and RF autoantibodies are early processes in RA.
Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus ResearchMonoclonal and Polyclonal Antibodies ResearchRheumatoid arthritisRheumatoid factorMedicineImmunologyAntibodyCyclic peptideImmunoglobulin APeptideImmunoglobulin GBiology
MeSH terms
AdultAgedArthritis, RheumatoidAutoantibodiesCitrullineFemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMiddle AgedPredictive Value of TestsRheumatoid FactorCohort Studies
Funding
- Reumatikerförbundet
Citations
1,939
FWCI
46.21
field-weighted impact
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23
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100%
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References
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
Arthritis & Rheumatism · 2000 · 1,452 citations
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis
Arthritis & Rheumatism · 1988 · 19,868 citations
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