articleTop 1% cited

Protective and pathological roles of nitric oxide in endotoxin shock

Cardiovascular Research · 1992 · Vol. 26(1) · pp. 48–57

Christine E. Wright✉(Wellcome Trust)Daryl D. Rees(Wellcome Trust)S. Moncada(Wellcome Trust)

Abstract

Inhibition of both constitutive and inducible NO synthases during endotoxaemia is deleterious. This can be overcome by replacing NO intravenously with a donor of NO. Selective inhibition of the inducible NO synthase may, however, be beneficial in shock.

Nitric Oxide and Endothelin Effects Neutrophil, Myeloperoxidase and Oxidative Mechanisms Eicosanoids and Hypertension PharmacologyWrightObituaryMedicineHistoryLibrary scienceArt historyClassicsArchaeology

MeSH terms

AnimalsArginineBlood PressureDexamethasoneDisease Models, AnimalHeart RateMaleNitric OxidePenicillamineRabbitsRegional Blood FlowShock, Septicomega-N-MethylarginineS-Nitroso-N-Acetylpenicillamine

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593

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34.54

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Hemodynamic actions of insulin