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Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease

Heart · 2004 · Vol. 90(4) · pp. 400–405

Andreas Boldt✉(Leipzig Heart Institute)U Wetzel(Leipzig Heart Institute)J Lauschke(Leipzig Heart Institute)J Weigl(Leipzig Heart Institute)J Gummert(Leipzig Heart Institute)G Hindricks(Leipzig Heart Institute)H Kottkamp(Leipzig Heart Institute)S Dhein(Leipzig Heart Institute)

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Abstract

AF is associated with fibrosis. Forms of AF differ from each other in collagen III expression. However, there was no systematic difference in ECM expression between paroxysmal AF and chronic AF. Enhanced concentrations of ECM proteins may have a role in structural remodelling and the pathogenesis of AF as a result of separation of the cells by fibrotic depositions.

Atrial Fibrillation Management and Outcomes Cardiac Fibrosis and Remodeling Cardiac Valve Diseases and TreatmentsAtrial fibrillationSinus rhythmFibrosisInternal medicineExtracellular matrixMedicineFibronectinCardiologyMitral valveImmunohistochemistry

MeSH terms

Atrial FibrillationChronic DiseaseFibronectinsFibrosisHeart AtriaHeart Valve DiseasesHumansImmunohistochemistryMiddle AgedMitral ValveBlotting, WesternCase-Control StudiesCollagen Type ICollagen Type III

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462

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7.37

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Cited by

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation