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Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

Hepatology · 2006 · Vol. 45(1) · pp. 42–52

Sandrine Boyault(Inserm)David S. Rickman(La Ligue Contre le Cancer)Aurélien de Reyniès(La Ligue Contre le Cancer)Charles Balabaud(Bordeaux Population Health)Sandra Rebouissou(Inserm)Emmanuelle Jeannot(Inserm)Aurélie Hérault(Inserm)Jean Saric(Centre Hospitalier Universitaire de Bordeaux)Jacques Belghiti(Hôpital Beaujon)Dominique Franco(Centre Hospitalier Universitaire de Bordeaux)Paulette Bioulac‐Sage(Université de Bordeaux)Pierre Laurent‐Puig(Université Paris Cité)Jessica Zucman‐Rossi✉(Fondation Jean Dausset-CEPH)

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Abstract

These results have furthered our understanding of the genetic diversity of human HCC and have provided specific identifiers for classifying tumors. In addition, our classification has potential therapeutic implications because 50% of the tumors were related to WNT or AKT pathway activation, which potentially could be targeted by specific inhibiting therapies.

Cancer-related Molecular Pathways Epigenetics and DNA Methylation Cancer Genomics and DiagnosticsTranscriptomeGeneComputational biologyMedicineBioinformaticsBiologyCancer researchGene expressionGenetics

MeSH terms

AdenomaDNA, NeoplasmFemaleMultigene FamilyCarcinoma, HepatocellularHumansLiver NeoplasmsMaleMiddle AgedMutationTranscription, GeneticSignal TransductionGene Expression Regulation, NeoplasticTumor Suppressor Protein p53Cell Cycle Proteins

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Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma