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A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization
Bulletin of the Chemical Society of Japan · 1979 · Vol. 52(7) · pp. 1989–1993
Junji Inanaga✉(Kyushu University)Kuniko Hirata(Kyushu University)Hiroko SAEKI(Kyushu University)Tsutomu Katsuki(Kyushu University)Masaru Yamaguchi(Kyushu University)
Abstract
Abstract A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including Dl-2,4,6-tridemethyl-3-deoxymethynolide.
Analytical Chemistry and ChromatographySynthetic Organic Chemistry MethodsAnalytical Methods in PharmaceuticalsChemistryRing (chemistry)Organic chemistryLactoneCombinatorial chemistry
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