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Long-term Electrical Capsular Stimulation in Patients with Obsessive-Compulsive Disorder

Neurosurgery · 2003 · Vol. 52(6) · pp. 1263–1274

Bart Nuttin✉(Karolinska Institutet)Loes Gabriëls(Karolinska Institutet)Paul Cosyns(Karolinska Institutet)Björn A. Meyerson(Karolinska Institutet)Sergej Andréewitch(Karolinska Institutet)Stefan Sunaert(Karolinska Institutet)Alex Maes(Karolinska Institutet)Patrick Dupont(Karolinska Institutet)J. Gybels(Karolinska Institutet)Frans Gielen(Karolinska Institutet)Hilde Demeulemeester(Karolinska Institutet)

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Abstract

These observations indicate that capsular stimulation reduces core symptoms 21 months after surgery in patients with severe, long-standing, treatment-refractory obsessive-compulsive disorder. The stimulation elicited changes in regional brain activity as measured by functional magnetic resonance imaging and positron emission tomography.

Obsessive-Compulsive Spectrum Disorders Neurological disorders and treatments Botulinum Toxin and Related Neurological DisordersMedicineStimulationDeep brain stimulationPositron emission tomographyAnesthesiaSurgeryNuclear medicineInternal medicine

MeSH terms

AdultBrainChronic DiseaseDouble-Blind MethodElectrodes, ImplantedElectric Stimulation TherapyFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSeverity of Illness Index

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Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder