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Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)

Diabetes Care · 1997 · Vol. 20(4) · pp. 614–620

Kalevi Pyörälà✉(National University Hospital of Iceland)Terje R. PedersenJohn Kjekshus(National University Hospital of Iceland)Ole Færgeman(National University Hospital of Iceland)Anders Olsson(National University Hospital of Iceland)Guðmundur Þorgeirsson(Linköping University Hospital)The Scandinavian Simvastatin Survival Study (4S) Group

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Abstract

The results strongly suggest that cholesterol lowering with simvastatin improves the prognosis of diabetic patients with CHD. The absolute clinical benefit achieved by cholesterol lowering may be greater in diabetic than in nondiabetic patients with CHD because diabetic patients have a higher absolute risk of recurrent CHD events and other atherosclerotic events.

Lipoproteins and Cardiovascular Health Cardiac Imaging and Diagnostics Antiplatelet Therapy and Cardiovascular DiseasesMedicineSimvastatinInternal medicineMyocardial infarctionDiabetes mellitusUnstable anginaAnginaCholesterolCardiologyRelative risk

MeSH terms

Anticholesteremic AgentsArteriosclerosisBlood PressureCholesterolCoronary DiseaseDiabetic AngiopathiesDouble-Blind MethodFemaleHumansCholesterol, HDLCholesterol, LDLLovastatinMaleMiddle AgedMyocardial Infarction

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