article Open AccessTop 10% cited
The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
Anesthesiology · 2003 · Vol. 98(2) · pp. 428–436
Laura E. Nelson✉(Imperial College London)Jun Lu(Harvard University)Tian‐Zhi Guo(Imperial College London)Clifford B. Saper(Imperial College London)Nicholas P. Franks(Harvard University)Mervyn Maze(Imperial College London)
Abstract
The authors propose that endogenous sleep pathways are causally involved in dexmedetomidine-induced sedation; dexmedetomidine's sedative mechanism involves inhibition of the LC, which disinhibits VLPO firing. The increased release of GABA at the terminals of the VLPO inhibits TMN firing, which is required for the sedative response.
Sleep and Wakefulness ResearchNeuroscience and Neuropharmacology ResearchMemory and Neural MechanismsDexmedetomidineAtipamezoleMedicineAgonistNon-rapid eye movement sleepPharmacologySedativeAlpha-2 adrenergic receptorAnesthesiaEndocrinology
MeSH terms
Adrenergic alpha-AgonistsAdrenergic alpha-AntagonistsAnimalsCell CountElectroencephalographyElectromyographyPostural BalanceGene Expression RegulationHypnotics and SedativesIbotenic AcidImidazolesImmunohistochemistryMice, Inbred C57BLNeural PathwaysPyridazines
Funding
- Vanderbilt University
Citations
846
FWCI
7.79
field-weighted impact
References
1
Percentile
98%
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Citations per year
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