reviewTop 1% cited
Role of Oxidants in Ischemic Brain Damage
Stroke · 1996 · Vol. 27(6) · pp. 1124–1129
Pak H. Chan✉(Neurological Surgery)
Abstract
I conclude that molecular genetic approaches in modifying antioxidant levels in the brain offer a unique tool for understanding the role of oxidants in ischemic brain damage.
Mitochondrial Function and PathologyFree Radicals and AntioxidantsBiochemical effects in animalsSuperoxide dismutaseIschemiaMedicineReperfusion injuryPharmacologyNitric oxide synthaseGenetically modified mouseCatalaseBrain damageNitric oxide
MeSH terms
AnimalsAntioxidantsBrain ChemistryBrain Damage, ChronicBrain IschemiaDisease Models, AnimalFree RadicalsMice, TransgenicProtein-Tyrosine KinasesProto-Oncogene ProteinsSuperoxide DismutaseOxidantsMice, KnockoutNeuroprotective AgentsGTP-Binding Proteins
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References
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
Biochemical Journal · 1973 · 2,606 citations
Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca<sup>2+</sup> Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons
Journal of Neurochemistry · 1995 · 616 citations
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
Proceedings of the National Academy of Sciences · 1990 · 7,036 citations
Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion
Journal of Cerebral Blood Flow & Metabolism · 1993 · 624 citations
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