review Open Access
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Cochrane Database of Systematic Reviews · 2002 · pp. CD001447–CD001447
R G Miller✉(California Pacific Medical Center)JD Mitchell(Royal Preston Hospital)Mary Lyon(Amyotrophic Lateral Sclerosis Association)DH Moore(California Pacific Medical Center)
Abstract
Riluzole 100 mg daily is reasonably safe and probably prolongs survival by about two months in patients with amyotrophic lateral sclerosis. More studies are needed, especially to clarify its effect in older patients (over 75 years), and those with more advanced disease.
Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchSynthetic Organic Chemistry MethodsRiluzoleAmyotrophic lateral sclerosisMedicinePlaceboHazard ratioAdverse effectClinical trialRandomized controlled trialInternal medicineDisease
MeSH terms
Amyotrophic Lateral SclerosisHumansExcitatory Amino Acid AntagonistsRiluzole
Citations
910
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field-weighted impact
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48
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References
El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis
Journal of the Neurological Sciences · 1994 · 2,124 citations
Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial
The Lancet Neurology · 2006 · 1,135 citations
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
Statistics in Medicine · 1998 · 4,805 citations
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