articleTop 10% cited
Neurological Deficit and Extent of Neuronal Necrosis Attributable to Middle Cerebral Artery Occlusion in Rats
Stroke · 1995 · Vol. 26(4) · pp. 627–635
Julio Herrero García✉(Henry Ford Hospital)Simone Wagner(Henry Ford Hospital)Kai-Feng Liu(Henry Ford Hospital)Xiao-jiang Hu(Henry Ford Hospital)
Abstract
The histological effects of an intracranial arterial occlusion in the adult rat can be predicted on day 1 by the neurological score described in this report. Significant improvement can be obtained in these animals by reestablishing arterial flow 60 minutes or sooner after the ictus. The pattern of cortical pannecrosis observed after permanent occlusion (> or = 72 hours) was transformed into incomplete ischemic injury in most instances of transient occlusion.
Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsBarrier Structure and Function StudiesMedicineOcclusionLesionMiddle cerebral arteryNecrosisInternal carotid arteryCerebral blood flowIschemiaNeurological deficitAnesthesia
MeSH terms
AnimalsArterial Occlusive DiseasesBrainCerebral Arterial DiseasesDisease Models, AnimalNecrosisNeurologic ExaminationRats, WistarRats
Citations
1,479
FWCI
9.40
field-weighted impact
References
36
Percentile
98%
vs. same field & year
Citations per year
Cited by
Ischemic Cell Death in Brain Neurons
Physiological Reviews · 1999 · 3,021 citations
References
Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.
Stroke · 1977 · 1,104 citations
Reversible middle cerebral artery occlusion without craniectomy in rats.
Stroke · 1989 · 7,411 citations
Thresholds in cerebral ischemia - the ischemic penumbra.
Stroke · 1981 · 2,827 citations
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Stroke · 1986 · 2,685 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.