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Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
Nature Protocols · 2009 · Vol. 4(12) · pp. 1798–1806
Florence Debacq‐Chainiaux✉(University of Namur)Jorge D. Erusalimsky(Cardiff Metropolitan University)Judith Campisi(Buck Institute for Research on Aging)Olivier Toussaint(University of Namur)
Telomeres, Telomerase, and SenescenceAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionSenescenceIn vivoCell biologyCell cultureBiologyTissue cultureBiomarkerIn vitroBiochemistryMolecular biology
MeSH terms
beta-GalactosidaseFluoresceinsGalactosidesHistocytochemistryHydrogen-Ion ConcentrationLysosomesMicroscopy, FluorescenceBiomarkersCellular Senescence
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References
Cellular senescence: when bad things happen to good cells
Nature Reviews Molecular Cell Biology · 2007 · 4,259 citations
Oxidative stress shortens telomeres
Trends in Biochemical Sciences · 2002 · 2,503 citations
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences · 1995 · 7,364 citations
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Nature Cell Biology · 2009 · 2,118 citations
Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
Journal of Cell Science · 2000 · 846 citations
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