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ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Current Biology · 2009 · Vol. 19(22) · pp. 1875–1885

Vandhana Muralidharan-Chari✉(University of Notre Dame)James Clancy(University of Notre Dame)Carolyn Plou(University of Notre Dame)Maryse Romao(Institut Curie)Philippe Chavrier(Institut Curie)Graça Raposo(Institut Curie)Crislyn D’Souza‐Schorey(University of Notre Dame)

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Cellular transport and secretion Protease and Inhibitor Mechanisms Extracellular vesicles in diseaseMicrovesicleMicrovesiclesCell biologyBiologyGuanine nucleotide exchange factorAdherens junctionProtein kinase AKinaseGTPaseBiochemistry

MeSH terms

ADP-Ribosylation Factor 6Cell MembraneHumansNeoplasm InvasivenessADP-Ribosylation Factors

Funding

National Science Foundation
National Cancer Institute

Citations

852

FWCI

5.73

field-weighted impact

References

Percentile

97%

vs. same field & year

Citations per year

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References

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Nature Cell Biology · 2008 · 1,988 citations

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Leukemia · 2006 · 1,623 citations

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Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

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Dissemination and growth of cancer cells in metastatic sites

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Rho GTPases in cancer cell biology

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