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Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)
Biochemical Pharmacology · 1992 · Vol. 43(7) · pp. 1545–1553
Mitchell Fry(Wellcome Trust)Mary Pudney✉(Wellcome Trust)
Bioactive Compounds and Antitumor AgentsMalaria Research and ControlPharmacological Effects of Natural CompoundsStereochemistryCoenzyme Q – cytochrome c reductasePlasmodium falciparumRespiratory chainMitochondrial respiratory chainPlasmodium yoeliiCytochrome bChemistryMechanism of actionMitochondrion
MeSH terms
AnimalsAntimalarialsBinding SitesLiverMitochondriaNADH DehydrogenaseNaphthoquinonesPlasmodium falciparumElectron Transport Complex IIIRatsAtovaquone
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