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Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy

AIDS · 2014 · Vol. 28(8) · pp. 1193–1202

Margaret May✉(University of Bristol)Mark Gompels(North Bristol NHS Trust)Valérie Delpech(Public Health England)Kholoud Porter(Medical Research Council)Chloe Orkin(Barts Health NHS Trust)Stephen Kegg(South London Healthcare NHS Trust)Phillip Hay(St George’s University Hospitals NHS Foundation Trust)Margaret Johnson(Royal Free London NHS Foundation Trust)Adrian Palfreeman(University Hospitals of Leicester NHS Trust)Richard Gilson(Mortimer Market Centre)David Chadwick(South Tees Hospitals NHS Foundation Trust)Fabiola Martin(York Teaching Hospital NHS Foundation Trust)Teresa HillJohn Walsh(Imperial College Healthcare NHS Trust)Frank Post(King's College Hospital NHS Foundation Trust)Martin Fisher(University Hospitals Sussex NHS Foundation Trust)Jonathan Ainsworth(North Middlesex University Hospital NHS Trust)Sophie JoséClifford Leen(NHS Lothian)Mark Nelson(Chelsea and Westminster Hospital NHS Foundation Trust)Jane Anderson(Homerton University Hospital)Caroline Sabin(Apple (Israel))

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Abstract

Successfully treated HIV-positive individuals have a normal life expectancy. Patients who started ART with a low CD4 cell count significantly improve their life expectancy if they have a good CD4 cell count response and undetectable viral load.

HIV/AIDS Research and Interventions HIV-related health complications and treatments HIV Research and TreatmentViral loadMedicineLife expectancyAntiretroviral therapyConfidence intervalPopulationMortality rateHuman immunodeficiency virus (HIV)ImmunologyInternal medicine

MeSH terms

AdultAgedAged, 80 and overFemaleUnited KingdomHumansLife ExpectancyMaleMiddle AgedHIV-1HIV InfectionsTreatment OutcomeCD4 Lymphocyte CountViral LoadAnti-Retroviral Agents