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Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: a double-blind, randomized, placebo-controlled study

The American Journal of Gastroenterology · 2003 · Vol. 98(2) · pp. 412–419
Mark PimentelEvelyn J. ChowHenry C. Lin

Abstract

An abnormal LBT is common in subjects with IBS. Normalization of LBT with neomycin leads to a significant reduction in IBS symptoms. The type of gas seen on LBT is also associated with IBS subgroup.

Gastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studiesWhipple's Disease and InterleukinsMedicinePlaceboLactuloseInternal medicineNeomycinIrritable bowel syndromeGastroenterologyConstipationBreath testDefecation

MeSH terms

AdultAnti-Bacterial AgentsBreath TestsColonic Diseases, FunctionalDouble-Blind MethodFemaleHumansLactuloseMaleNeomycinCase-Control Studies

Funding

  • Beatrice and Samuel A. Seaver Foundation
  • Cedars-Sinai Medical Center
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