articleTop 1% cited
Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors
AIDS · 1999 · Vol. 13(10) · pp. F63–F70
Georg M. N. Behrens✉(Medizinische Hochschule Hannover)André DejamHartmut SchmidtH.J. BalksGeorg BrabantT. KörnerMatthias StollReinhold Schmidt
Abstract
Combination drug regimens including PI are accompanied by impaired glucose tolerance, hyperproinsulinaemia as an indicator for beta-cell dysfunction, and lipid abnormalities proved to be significant risk factors for coronary heart disease. Moreover, PI may have an impact on the processing of proinsulin to insulin.
HIV-related health complications and treatmentsHIV/AIDS drug development and treatmentHIV Research and TreatmentProteaseLipid metabolismMetabolismBETA (programming language)MedicineCarbohydrate metabolismHuman immunodeficiency virus (HIV)PharmacologyChemistryBiology
MeSH terms
HIV Protease InhibitorsAdultAgedBlood GlucoseCoronary DiseaseCross-Sectional StudiesFemaleHumansHyperinsulinismHyperlipidemiasInsulinIslets of LangerhansLipoproteinsMaleMiddle Aged
Citations
526
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45.33
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27
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