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5-HIAA in the Cerebrospinal Fluid

Archives of General Psychiatry · 1976 · Vol. 33(10) · pp. 1193–1193

Marie Åsberg✉(Karolinska University Hospital)

Abstract

The incidence of suicidal acts was studied in 68 depressed patients and related to the level of 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid. The distribution of 5-HIAA levels was bimodal. Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means. Two of the 20 patients in the low mode, and none of the 48 patients in the high mode died from suicide.

Neurotransmitter Receptor Influence on Behavior Treatment of Major Depression Functional Brain Connectivity StudiesCerebrospinal fluidIncidence (geometry)Medicine5-Hydroxyindoleacetic acidInternal medicinePsychiatryPsychologyGastroenterologySerotoninPhysics

MeSH terms

Adjustment DisordersAdultAgedDepressionFemaleHumansHydroxyindoleacetic AcidMaleMiddle AgedPsychiatric Status Rating ScalesSerotoninSuicideSuicide, AttemptedViolence

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Aggression in humans correlates with cerebrospinal fluid amine metabolites