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Natural history of HIV infection in the_era of combination antiretroviral therapy
AIDS · 1999 · Vol. 13(14) · pp. 1933–1942
Richard D. Moore✉(Johns Hopkins Medicine)Richard E. Chaisson(Johns Hopkins Medicine)
Abstract
We observed a significant decline in the incidence of opportunistic illness and death from 1994 through 1998 associated with combination antiretroviral therapy. Patients who develop events while being treated with PI combination therapy were not likely to have achieved an undetectable HIV-1 RNA and are likely to have a low concurrent CD4 level.
HIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and InterventionsIncidence (geometry)MedicineInternal medicineAntiretroviral therapyConfidence intervalRelative riskImmunologyViral loadHuman immunodeficiency virus (HIV)Pediatrics
MeSH terms
Drug Therapy, CombinationHumansLongitudinal StudiesMortalityRNA, ViralHIV-1HIV InfectionsIncidenceAIDS-Related Opportunistic InfectionsHIV Protease InhibitorsAnti-HIV Agents
Citations
455
FWCI
22.62
field-weighted impact
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26
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100%
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References
Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
New England Journal of Medicine · 1998 · 9,489 citations
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